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NSC 625987

CAS No. 141992-47-4

NSC 625987 ( NSC 625987; NSC-625987; NSC625987; Cdk4 Inhibitor II )

Catalog No. M11755 CAS No. 141992-47-4

NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NSC 625987
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
  • Description
    NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
  • Synonyms
    NSC 625987; NSC-625987; NSC625987; Cdk4 Inhibitor II
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    141992-47-4
  • Formula Weight
    271.33
  • Molecular Formula
    C15H13NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    S=C1C2=C(C=CC=C2)NC3=C(OC)C=CC(OC)=C13
  • Chemical Name
    1,4-Dimethoxy-9(10H)-acridinethione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kubo A, et al. Clin Cancer Res. 1999 Dec;5(12):4279-86.
2. McInnes C, et al. Chem Biol. 2004 Apr;11(4):525-34.
3. Lang E, et al. Cell Physiol Biochem. 2015;37(3):1178-86.
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