NSC 625987 ( NSC 625987; NSC-625987; NSC625987; Cdk4 Inhibitor II )

Catalog No. M11755 CAS No. 141992-47-4

NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

NSC 625987
Note

Research use only, not for human use.
Brief Description

NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
Description

NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
Synonyms

NSC 625987; NSC-625987; NSC625987; Cdk4 Inhibitor II
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

Chemical Information

CAS Number

141992-47-4
Formula Weight

271.33
Molecular Formula

C15H13NO2S
Purity

>98% (HPLC)
Solubility

——
SMILES

S=C1C2=C(C=CC=C2)NC3=C(OC)C=CC(OC)=C13
Chemical Name

1,4-Dimethoxy-9(10H)-acridinethione

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kubo A, et al. Clin Cancer Res. 1999 Dec;5(12):4279-86.
2. McInnes C, et al. Chem Biol. 2004 Apr;11(4):525-34.
3. Lang E, et al. Cell Physiol Biochem. 2015;37(3):1178-86.

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